136583-51-2Relevant academic research and scientific papers
Reaction of Tantalum-Alkyne Complexes with Isocyanates or Acyl Cyanides. Stereoselective Functionalization of Carbon-Carbon Triple Bonds
Kataoka, Yasutaka,Oguchi, Yoshiyuki,Yoshizumi, Kazuyuki,Miwatashi, Seiji,Takai, Kazuhiko,Utimoto, Kiitiro
, p. 1543 - 1549 (2007/10/02)
Treatment of alkynes with low-valent tantalum derived from TaCl5 and zinc produces tantalum-alkyne complexes (not isolated), which react in situ with phenyl isocyanate (or butyl isocyanate) to give (E)-α,β-unsaturated amides stereoselectively.The tantalum-alkyne complexes also react with acyl cyanides in the presence of BF3*OEt2 to give α-cyanohydrins.In both reactions, filtration of the reaction mixture containing the tantalum-alkyne complexes before addition of isocyanates (or acyl cyanides) is indispensable to obtain good yields.
Reaction of Tantalum-Alkyne Complexes with Isocyanates Leading to (E)-α,β-Unsaturated Amides. Stereoselective Functionalization of Carbon-Carbon Triple Bonds
Takai, Kazuhiko,Kataoka, Yasutaka,Yoshizumi, Kazuyuki,Oguchi, Yoshiyuki,Utimoto, Kiitiro
, p. 1479 - 1482 (2007/10/02)
Treatment of alkynes with low-valent tantalum derived from TaCl5 and zinc produces tantalum-alkyne complexes (not isolated), which react with phenylisocyanate (or butylisocyanate) to give (E)-α,β-unsaturated amides stereoselectively.
