136584-14-0

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID
• Synonyms: 1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID;AKOS BC-0607;AURORA KA-827;TIMTEC-BB SBB011130;1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID, 95+%;(3-Oxo-1,2,3,4-tetrahydro-quinoxalin-2-yl)-acetic acid;2-(3-Oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetic acid;2-(3-keto-2,4-dihydro-1H-quinoxalin-2-yl)acetic acid
• CAS NO: 136584-14-0
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.2
• Mol File: 136584-14-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 169-170 °C
• Boiling Point: 526.6°Cat760mmHg
• Flash Point: 272.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 6.44E-12mmHg at 25°C
• PKA: 4.04±0.10(Predicted)
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID(136584-14-0)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID(136584-14-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 136584-14-0(Hazardous Substances Data)

Usage

Description

1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID, also known as THA, is a synthetic chemical compound with the molecular formula C11H11NO4. It is a derivative of quinolinic acid and has been identified as a potential neuroprotective agent. THA possesses antioxidant and anti-inflammatory properties, which have been the subject of research for its potential role in treating Alzheimer's disease and other neurodegenerative disorders. Its ability to inhibit the production of amyloid beta, a protein linked to Alzheimer's, makes it a promising candidate for further investigation as a therapeutic agent for neurological conditions.

Uses

Used in Pharmaceutical Industry:
1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID is used as a neuroprotective agent for its potential therapeutic effects in treating Alzheimer's disease and other neurodegenerative disorders. Its antioxidant and anti-inflammatory properties contribute to its potential as a treatment option, particularly due to its ability to inhibit the production of amyloid beta, a key protein associated with Alzheimer's disease.
Used in Research and Development:
1,2,3,4-TETRAHYDRO-3-OXO-2-QUINOXALINEACETIC ACID is utilized in ongoing research to further explore its potential as a therapeutic agent for neurological conditions. Its antioxidant and anti-inflammatory properties, along with its capacity to inhibit amyloid beta production, make it a valuable compound for scientific investigation into the prevention and treatment of neurodegenerative diseases.

InChI:InChI=1/C10H10N2O3/c13-9(14)5-8-10(15)12-7-4-2-1-3-6(7)11-8/h1-4,8,11H,5H2,(H,12,15)(H,13,14)/p-1/t8-/m1/s1

Upstream product

• 56-84-8 L-Aspartic acid 
• 1493-27-2 ortho-nitrofluorobenzene 
• 136584-15-1 2-(3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-acetamide 

Downstream Products

• 625437-93-6 2-(3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)-N-phenethyl-acetamide 

Relevant articles and documents

SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS

Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists to relieve symptons, associated with bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.