136587-13-8

Basic information

• Product Name: SPERMINE NONOATE
• Synonyms: (Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE;SPERMINE BIS (NITRIC OXIDE) ADDUCT;SPERMINE/NITRIC OXIDE COMPLEX;SPERMINE NONOATE;SPER/NO;NOC-22;N-[4-[1-(3-AMINOPROPYL)-2-HYDROXY-2-NITROSOHYDRAZINO]BUTYL]-1,3-PROPANEDIAMINE
• CAS NO: 136587-13-8
• Molecular Formula: C10H26N6O2
• Molecular Weight: 262.35
• Product Categories: Nitric Oxide Reagents;Amines
• Mol File: 136587-13-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 405.6°C (rough estimate)
• Flash Point: 211.1 °C
• Appearance: white/
• Density: 1.0879 (rough estimate)
• Vapor Pressure: 5.07E-09mmHg at 25°C
• Refractive Index: 1.7000 (estimate)
• Storage Temp.: -20°C
• Solubility: methanol: ≥1mg/mL
• PKA: 5.47±0.69(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.
• CAS DataBase Reference: SPERMINE NONOATE(CAS DataBase Reference)
• NIST Chemistry Reference: SPERMINE NONOATE(136587-13-8)
• EPA Substance Registry System: SPERMINE NONOATE(136587-13-8)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 136587-13-8(Hazardous Substances Data)

Usage

Description

Spermine NONOate (136587-13-8) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner.? ? The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 min at 37 °C, or 230 min at room temperature.1? ? Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 136587-13-8 differently. You can refer to the following data:
1. A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies
2. A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies.

General Description

Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t?) of NO release = 230 min (PBS, pH 7.4, 22°C).

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t=39 min at 37℃, pH 7.4, aqueous solution).

Biochem/physiol Actions

Product does not compete with ATP.

References

1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281

InChI:InChI=1/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2/p+3

Related news

A comparative study of NONOate based NO donors: SPERMINE NONOATE (cas 136587-13-8) is the best suited NO donor for angiogenesis09/03/2019

Nitric oxide (NO) is a known modulator of angiogenesis. The NONOate subfamily of NO donors has long been used in experimental and clinical studies to promote angiogenesis. However, no studies have been conducted yet to compare the angiogenesis potential of these NO donors in respect to their pat...detailed