Spermine NONOate, also known as 136587-13-8, is a nitric oxide donor that forms a complex with nitric oxide (NO). It is an off-white solid that dissociates into the free amine and NO in a pH-dependent manner, making it a convenient reagent for preparing aqueous solutions of NO.

136587-13-8

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Basic information
1. Product Name: SPERMINE NONOATE
2. Synonyms: (Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE;SPERMINE BIS (NITRIC OXIDE) ADDUCT;SPERMINE/NITRIC OXIDE COMPLEX;SPERMINE NONOATE;SPER/NO;NOC-22;N-[4-[1-(3-AMINOPROPYL)-2-HYDROXY-2-NITROSOHYDRAZINO]BUTYL]-1,3-PROPANEDIAMINE
3. CAS NO:136587-13-8
4. Molecular Formula: C10H26N6O2
5. Molecular Weight: 262.35
6. EINECS: N/A
7. Product Categories: Nitric Oxide Reagents;Amines
8. Mol File: 136587-13-8.mol
Chemical Properties
1. Melting Point: 105-107°C
2. Boiling Point: 405.6°C (rough estimate)
3. Flash Point: 211.1 °C
4. Appearance: white/
5. Density: 1.0879 (rough estimate)
6. Vapor Pressure: 5.07E-09mmHg at 25°C
7. Refractive Index: 1.7000 (estimate)
8. Storage Temp.: -20°C
9. Solubility: methanol: ≥1mg/mL
10. PKA: 5.47±0.69(Predicted)
11. Stability: Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.
12. CAS DataBase Reference: SPERMINE NONOATE(CAS DataBase Reference)
13. NIST Chemistry Reference: SPERMINE NONOATE(136587-13-8)
14. EPA Substance Registry System: SPERMINE NONOATE(136587-13-8)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: 22-24/25
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 136587-13-8(Hazardous Substances Data)

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136587-13-8 Usage

Uses

Used in In Vitro Studies:
Spermine NONOate is used as a reagent for releasing Nitric Oxide into aqueous solutions at controlled rates. This application is particularly useful for in vitro studies, where controlled release of NO is essential for understanding its biological effects and interactions with various cellular components.
The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 minutes at 37°C or 230 minutes at room temperature. At a pH of 5.0, the dissociation is essentially instantaneous. This property allows researchers to study the effects of nitric oxide in a controlled manner, making Spermine NONOate a valuable tool in various research applications.

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t=39 min at 37℃, pH 7.4, aqueous solution).

Biochem/physiol Actions

Product does not compete with ATP.

References

1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281

Check Digit Verification of cas no

The CAS Registry Mumber 136587-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,5,8 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 136587-13:
(8*1)+(7*3)+(6*6)+(5*5)+(4*8)+(3*7)+(2*1)+(1*3)=148
148 % 10 = 8
So 136587-13-8 is a valid CAS Registry Number.

InChI:InChI=1/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,18H,1-12H2/p+3

136587-13-8 Well-known Company Product Price

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Sigma
(S150) Spermine–Nitric oxide complex source of nitric oxide
136587-13-8
S150-25MG
1,814.67CNY
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136587-13-8Related news

A comparative study of NONOate based NO donors: SPERMINE NONOATE (cas 136587-13-8) is the best suited NO donor for angiogenesis09/03/2019

Nitric oxide (NO) is a known modulator of angiogenesis. The NONOate subfamily of NO donors has long been used in experimental and clinical studies to promote angiogenesis. However, no studies have been conducted yet to compare the angiogenesis potential of these NO donors in respect to their pat...detailed

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