1365910-41-3Relevant academic research and scientific papers
Palladium-Catalyzed Highly Regioselective Aromatic Substitution of Benzylic Ammonium Salts with Amines
Xu, Ya-Nan,Zhu, Meng-Zeng,Lin, Yu-Kun,Tian, Shi-Kai
, p. 7169 - 7173 (2019/09/13)
An unprecedented aromatic substitution reaction of benzylic ammonium salts has been developed through palladium-catalyzed C-N bond cleavage. A range of primary and secondary amines participated in a palladium-catalyzed aromatic substitution reaction of benzylic ammonium salts, delivering sterically hindered aromatic amines in moderate to excellent yields with extremely high regioselectivity. Preliminary mechanistic studies permitted successful identification of Π-benzylpalladium complexes and Γ-vinyl allylic amines as key intermediates. This study paves the way for the use of benzylic ammonium salts in the aromatic substitution reactions.
Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives with various amines
Zhang, Sheng,Wang, Yi,Feng, Xiujuan,Bao, Ming
supporting information; experimental part, p. 5492 - 5495 (2012/05/20)
Palladium-catalyzed amination of chloromethylnaphthalene and chloromethylanthracene derivatives to produce naphthylamines and anthrylamines in satisfactory to good yields has been developed. The unprecedented amination reactions proceeded smoothly under mild conditions in the presence of Pd(PPh3)4 as a catalyst.
