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1365970-48-4

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  • (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylic acid

    Cas No: 1365970-48-4

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  • high quality (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylic acid

    Cas No: 1365970-48-4

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  • (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylic acid

    Cas No: 1365970-48-4

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  • (33R,35S,91R,92R,5S,E)-5-(tert-butyl)-14,14-difluoro-4,7-dioxo-2,8,10-trioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopentanacyclotetradecaphan-12-ene-35-carboxylic acid

    Cas No: 1365970-48-4

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1365970-48-4 Usage

Uses

(3aR,7S,10S,12R,24aR)- 7-(1,1-Dimethylethyl)-20,20-difluoro-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-5,8-dioxo-10H-9,12-Methano-1H-cyclopenta[18,19][1,10,17,3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxylic Acid is an antiviral agent and a Glecaprevir (1365970-03-1) intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 1365970-48-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,5,9,7 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1365970-48:
(9*1)+(8*3)+(7*6)+(6*5)+(5*9)+(4*7)+(3*0)+(2*4)+(1*8)=194
194 % 10 = 4
So 1365970-48-4 is a valid CAS Registry Number.

1365970-48-4Downstream Products

1365970-48-4Relevant articles and documents

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification

Cink, Russell D.,Ding, Chen,Engstrom, Kenneth M.,Fickes, Michael G.,Henle, Jeremy,Kallemeyn, Jeffrey M.,Lukin, Kirill A.,Marren, James,Morrill, Westin H.,Nere, Nandkishor K.,Pelc, Matthew J.,Ravn, Matthew M.,Shekhar, Shashank,Towne, Timothy B.,Vinci, John C.,Wei, Haojuan,Welch, Dennie S.,Zhao, Gang

, p. 1373 - 1392 (2020)

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

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