1366019-76-2

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 136786-75-9 1H-3-(2-thienyl)-5-[4-(dimethylamino)phenyl]-Δ2-pyrazoline 
• 1262757-88-9 1-benzoyl-3-(2-thienyl)-5-[4-(dimethylamino)phenyl]-Δ2-pyrazoline 
• 137444-53-2 3-(4-dimethylaminophenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 88-15-3 2-Acetylthiophene 

Relevant academic research and scientific papers

Synthesis of 3,5-disubstituted pyrazoles and their derivatives

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.