1366068-04-3 Usage
Uses
Used in Pharmaceutical Research:
JWH 424 is used as a research compound for studying the effects and mechanisms of action at the CB1 and CB2 cannabinoid receptors. Its high potency and unique pharmacological profile make it a valuable tool for understanding the therapeutic potential of cannabinoids in various medical conditions.
Used in Drug Development:
JWH 424 serves as a lead compound in the development of new drugs targeting the cannabinoid system. Its potent agonist activity at CB1 and CB2 receptors can be leveraged to create medications with improved efficacy and safety profiles for the treatment of pain, inflammation, and other conditions responsive to cannabinoid modulation.
Used in Toxicological Studies:
Due to its association with adverse reactions and potential for abuse, JWH 424 is used in toxicological studies to investigate the risks and consequences of synthetic cannabinoid use. These studies aim to inform regulatory policies and public health strategies to mitigate the harms associated with these substances.
Used in Forensic Analysis:
JWH 424 is utilized in forensic analysis for the detection and identification of synthetic cannabinoids in biological samples, such as blood, urine, and hair. This helps in the investigation of drug-related crimes and the assessment of drug use patterns in various populations.
Used in Analytical Chemistry:
JWH 424 is employed as a reference material in the development and validation of analytical methods for the detection and quantification of synthetic cannabinoids in various matrices. This contributes to the improvement of analytical techniques and the accurate measurement of these compounds in research and regulatory contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 1366068-04-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,6,0,6 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1366068-04:
(9*1)+(8*3)+(7*6)+(6*6)+(5*0)+(4*6)+(3*8)+(2*0)+(1*4)=163
163 % 10 = 3
So 1366068-04-3 is a valid CAS Registry Number.
1366068-04-3Relevant articles and documents
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
Wiley, Jenny L.,Smith, Valerie J.,Chen, Jianhong,Martin, Billy R.,Huffman, John W.
, p. 2067 - 2081 (2012/06/01)
To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.
