136632-32-1

Basic information

• Product Name: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE
• Synonyms: Calpain Inhibitor II, ALLM;ALLM (Calpain Inhibitor) 95% purity;ALLM (Calpain Inhibitor);25 MG CALPAIN INHIBITOR IIRESEARCH GRADE;CALPAIN INHIBITOR II (N-AC-LEU-LEU METHIORINAL);N-acetyl-Leu-Leu-methional
• CAS NO: 136632-32-1
• Molecular Formula: C19H35N3O4S1
• Molecular Weight: 401.56
• EINECS: 603-969-3
• Product Categories: Calpain I;Calpain I Inhibitors;Calpain II;Calpain II Inhibitors;Carbonyl Compounds;Cathepsin B;Cathepsin/Granzyme Inhibitors &C-CH;Cell Biology;Cell Signaling and Neuroscience;Cell Signaling Enzymes;Chemical Synthesis;Endoplasmic Reticulum Stress;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Intracellular Protein Degradation;Lysosomal Proteases;Substrates;ProteasomeInhibitors;Protease;Nitric Oxide and Cell;A to C;Aldehydes;and Substrates;Apoptosis Enzymes;Application Index;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Calpain;Calpain and Proteasome Inhibitors
• Mol File: 136632-32-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 676.5°C at 760 mmHg
• Flash Point: 362.9°C
• Appearance: white/
• Density: 1.076g/cm³
• Vapor Pressure: 3.69E-18mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: −20°C
• Solubility: Soluble in ethanol at 20mg/ml
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
• BRN: 7693643
• CAS DataBase Reference: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(CAS DataBase Reference)
• NIST Chemistry Reference: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(136632-32-1)
• EPA Substance Registry System: 25 MG CALPAIN INHIBITOR IIRESEARCH GRADE(136632-32-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 136632-32-1(Hazardous Substances Data)

Usage

Description

ALLM (136632-32-1) is a cell-permeable, peptide aldehyde inhibitor of calpain (calpain I, Ki?= 120 nM, calpain II, Ki?= 230 nM) and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6 nM) and cathepsin B (Ki=100 nM).1?Weak inhibitor of the chymotrypsin-like activity of the proteasome.2?Cell permeable.

Uses

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II?in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins;?J. Enzyme Inhib.,?3?195 2) Vinitsky?et al.?(1992),?Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex; Biochemistry,?31?9421

InChI:InChI=1/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15?,16-,17?/m0/s1