136633-98-2Relevant academic research and scientific papers
An investigation into the alkylation of 1,2,4-triazole
Bulger, Paul G.,Cottrell, Ian F.,Cowden, Cameron J.,Davies, Antony J.,Dolling, Ulf-H.
, p. 1297 - 1301 (2007/10/03)
The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1- substituted-1,2,4-triazoles. (C) 2000 Elsevier Science Ltd.
An improved method for the N-alkylation of benzotriazole and 1,2,4-triazole
Katritzky, Alan R.,Kuzmierkiewiecz, Wojciech,Greenhill, John V.
, p. 369 - 373 (2007/10/02)
The N-alkylation of benzotriazole and 1,2,4-triazole with alkyl halides proceeds efficiently in the presence of sodium hydroxide in N,N-dimethylformamide.
