1366341-46-9

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 1239889-59-8 (S)-N-(1-benzyl-2-phenylsulfanylethyl)-2,2,2-trifluoroacetamide 
• 1431213-90-9 (S)-N-[1-benzyl-2-(4,6-dimethylpyrimidin-2-ylsulfanyl)ethyl]-2,2,2-trifluoroacetamide 
• 64889-55-0 (S)-2,2,2-trifluoro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 1431213-91-0 N-((S)-3-chloro-1-phenylpropan-2-yl)-2,2,2-trifluoroacetamide 
• 1431213-92-1 (S)-4-benzyl-2,2-bis(trifluoromethyl)oxazolidine 
• 1431213-93-2 (S)-N-trimethylsilanyl-4-benzyl-2,2-bis(trifluoromethyl)-oxazolidine 
• 1431213-85-2 (S)-2,2,2-trifluoro-N-(1-phenoxy-3-phenylpropan-2-yl)acetamide 
• 1431213-86-3 (S)-N-[1-benzyl-2-(4-nitrophenoxy)ethyl]-2,2,2-trifluoroacetamide 
• 1431213-87-4 (S)-N-[1-benzyl-2-(4-methoxyphenoxy)ethyl]-2,2,2-trifluoroacetamide 
• 1431213-88-5 (S)-N-[1-benzyl-2-(naphthalen-2-yloxy)ethyl]-2,2,2-trifluoroacetamide 
• 1431213-89-6 (S)-N-[1-benzyl-2-(pyridin-3-yloxy)ethyl]-2,2,2-trifluoroacetamide 

Relevant academic research and scientific papers

A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates

A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.