1366360-71-5Relevant academic research and scientific papers
Expedient access to an N-phenylpyrrolidin-2-yl heterocycle via a base-induced intramolecular aza-michael reaction
Ferreira Ramos, Josierika A.,Nagem, Tanus J.,Taylor, Jason G.
experimental part, p. 225 - 230 (2012/03/11)
Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)- 2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular aza-Michael reaction.
