13665-88-8 Usage
Originator
Rapenton,Thomae,W. Germany,1980
Manufacturing Process
3.9 g (0.06 mol) of zinc powder were introduced into a solution of 5.0 g (0.01
mol) of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-[5,4-d]-pyrimidine
(dipyridamole; see entry under that name for its synthesis) in 120 cc of
aqueous 10% formic acid. The resulting mixture was heated on a water bath,
while occasionally stirring, until the intense yellow color of the starting
compound disappeared, which occurred after about 30 to 40 minutes.
Thereafter, the unconsumed zinc powder was separated by vacuum filtration,
the virtually colorless filtrate was essentially an aqueous solution of 2,6-bis-
(diethanolamino)-8-piperidino-1,2,3,4-tetrahydropyrimido-[5,4-d]pyrimidine.The filtrate was adjusted to a pH of 9 by adding concentrated ammonia, and
then a 1 N aqueous iodine-potassium iodide solution was added dropwise,
whereby the tetrahydropyrimido[5,4-d]pyrimidine obtained by hydrogenation
with zinc in formic acid was converted by oxidation into 2,6-bis-
(diethanolamino)-8-piperidino-pyrimido-[5,4-d]-pyrimidine. The completion of
the oxidation was checked by means of a starch solution. The major amount
of the oxidation product already separated out as a deep yellow crystalline
precipitate during the addition of the iodine solution. After the oxidation
reaction was complete, the reaction mixture was allowed to stand for a short
period of time, and then the precipitate was separated by vacuum filtration,washed with water and dried. It had a melting point of 157°C to 158°C. The
yield was 8.0 g, which corresponds to 95% theory.
Therapeutic Function
Platelet aggregation inhibitor
Check Digit Verification of cas no
The CAS Registry Mumber 13665-88-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,6,6 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13665-88:
(7*1)+(6*3)+(5*6)+(4*6)+(3*5)+(2*8)+(1*8)=118
118 % 10 = 8
So 13665-88-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H31N7O4/c27-10-6-25(7-11-28)18-20-14-15-16(22-18)17(24-4-2-1-3-5-24)23-19(21-15)26(8-12-29)9-13-30/h14,27-30H,1-13H2
