136656-07-0

Basic information

• Product Name: Timosaponin BII
• Synonyms: Timosaponin B2;Timsaponin B-Ⅱ;Timosaponin BII;(25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol;(25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol;Anemarsaponin BII, 98%, from Anemarrhena asphodeloides Bunge
• CAS NO: 136656-07-0
• Molecular Formula: C45H76O19
• Molecular Weight: 921.076
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products
• Mol File: 136656-07-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1033.645 °C at 760 mmHg
• Flash Point: 573℃
• Appearance: /
• Density: 1.43
• Refractive Index: 1.627
• PKA: 12.85±0.70(Predicted)
• CAS DataBase Reference: Timosaponin BII(CAS DataBase Reference)
• NIST Chemistry Reference: Timosaponin BII(136656-07-0)
• EPA Substance Registry System: Timosaponin BII(136656-07-0)

Safety Data

• Hazardous Substances Data: 136656-07-0(Hazardous Substances Data)

Usage

Uses

Timosaponin B II is an Aβ-lowering modulators of amyloid precursor protein processing for the treatment of Alzheimer’s disease. Also, it is isolated from the rhizome of Anemarrhena asphodeloides which is widely used in traditional Chinese medicine.

InChI:InChI=1/C45H76O19/c1-19(18-58-40-37(55)34(52)31(49)27(15-46)60-40)7-12-45(57)20(2)30-26(64-45)14-25-23-6-5-21-13-22(8-10-43(21,3)24(23)9-11-44(25,30)4)59-42-39(36(54)33(51)29(17-48)62-42)63-41-38(56)35(53)32(50)28(16-47)61-41/h19-42,46-57H,5-18H2,1-4H3/t19-,20-,21+,22-,23+,24-,25-,26-,27+,28+,29+,30-,31+,32+,33-,34-,35-,36-,37+,38+,39+,40+,41-,42+,43-,44-,45?/m0/s1

Related news

Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of Timosaponin BII (cas 136656-07-0) in rats09/04/2019

Timosaponin BII (TBII), a major steroidal saponin isolated from Anemarrhena asphodeloides Bge., displays a variety of promising pharmacological activities, such as neuroprotection, enhancement of learning and memory, vascular protection and inhibition of platelet aggregation; therefore, it has b...detailed

Short communicationPreparation of some metabolites of Timosaponin BII (cas 136656-07-0) by biotransformation in vitro09/03/2019

Timosaponin BII (TBII) is an active constituent of some Chinese medicinal herbs, and is abundant in Anemarrhena asphodeloides Bunge. To better understand the pharmaceutical mechanisms of TBII, we prepared its deglycosylated derivatives through biotransformation with fungi Colletotrichum gloeospo...detailed