136665-72-0Relevant academic research and scientific papers
Two enantioselective syntheses of a precursor of the biologically most active isomer of CGA 80000 (clozylacon)
Buser,Pugin,Spindler,Sutter
, p. 5709 - 5716 (2007/10/02)
The unchlorinated precursor 4 of CGA 80000 (1) was synthesized enantioselectively by two conceptionally different routes: a) by a 'chiral pool' approach starting from L-malic acid and b) by enantioselective hydrogenation of an enamide intermediate, catalyzed by chiral Rh- or Ru-phosphine-complexes.
