136667-01-1

Basic information

• Product Name: 6-Methyl-4-((E)-3-phenyl-allyloxy)-pyran-2-one
• Synonyms: 6-Methyl-4-((E)-3-phenyl-allyloxy)-pyran-2-one
• CAS NO: 136667-01-1
• Molecular Weight: 242.274
• Mol File: 136667-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Methyl-4-((E)-3-phenyl-allyloxy)-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-4-((E)-3-phenyl-allyloxy)-pyran-2-one(136667-01-1)
• EPA Substance Registry System: 6-Methyl-4-((E)-3-phenyl-allyloxy)-pyran-2-one(136667-01-1)

Safety Data

• Hazardous Substances Data: 136667-01-1(Hazardous Substances Data)

Upstream product

• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 

Relevant articles and documents

Large rate accelerations in the stille reaction with tri-2-furylphosphine and triphenylarsine as palladium ligands: mechanistic and synthetic implications

The effect changing the palladium ligands on the rates of typical Stille cross-coupling reactions was studied. Large rate enhancements (typically 102-103 over triphenylphosphine-based catalysts) were observed with tri-2-furylphosphine (TFP) and triphenylarsine, which are recommended as the new ligands of choice in the palladium-catalyzed coupling between olefinic stannanes and electrophiles. On the basis of the evidence presented, the transmetalation, which is the rate-determining step in the catalytic cycle, is postulated to involve a π-complex between the metal and the stannane double bond. In general, ligands that readily dissociate from Pd(II) and allow ready formation of this π-complex are the ones that produce the fastest coupling rates. The utility of the new ligands is demonstrated with several synthetic examples.