13667-37-3

Basic information

• Product Name: 2,2-dichloro-N-(1,3-thiazol-2-yl)acetamide
• Synonyms: 2,2-dichloro-N-(1,3-thiazol-2-yl)acetamide
• CAS NO: 13667-37-3
• Molecular Formula: C5H4Cl2N2OS
• Molecular Weight: 211.0691
• Mol File: 13667-37-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.644 g/cm³
• Refractive Index: 1.647
• CAS DataBase Reference: 2,2-dichloro-N-(1,3-thiazol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-N-(1,3-thiazol-2-yl)acetamide(13667-37-3)
• EPA Substance Registry System: 2,2-dichloro-N-(1,3-thiazol-2-yl)acetamide(13667-37-3)

Safety Data

• Hazardous Substances Data: 13667-37-3(Hazardous Substances Data)

Usage

Common uses

Pesticide (Herbicide and Fungicide)
Utilized to control unwanted vegetation and pathogens in agricultural settings by inhibiting the growth of certain plants and fungi.

Industrial applications

Mold and mildew prevention
Incorporated in commercial and industrial products to prevent the growth of mold and mildew.

Safety precautions

Potential hazards
May be harmful if ingested or inhaled, and can cause skin and eye irritation.
It is essential to handle this chemical with caution to minimize health risks and environmental contamination.

InChI:InChI=1/C5H4Cl2N2OS/c6-3(7)4(10)9-5-8-1-2-11-5/h1-3H,(H,8,9,10)

Upstream product

• 96-50-4 2-thiazolylamine 
• 79-36-7 dichloroacethyl chloride 

Relevant articles and documents

Design, synthesis, molecular docking, biological evaluations and QSAR studies of novel dichloroacetate analogues as anticancer agent

Dichloroacetate (DCA) as a mitochondria-targeting small molecule, through inhibition of pyruvate dehydrogenase kinases (PDK1-4), promotes mitochondria-regulated apoptosis and hence, inhibits tumour growth and reduces its proliferation. In this study, a series of novel N-aryl-2,2-dichloroacetamide and aryl-2,2-dichloroacetate derivatives were designed and synthesized. Their cytotoxic activities against various human cancer cell lines including A549, HCA-7, MCF-7, MDA-MB-231, KB and SKOV3 were evaluated. These compounds showed satisfactory potencies with much higher anticancer activity than the parent compound DCA, against the studied cancer cell lines. Molecular docking studies were also done to find their binding site and types of their interactions with PDKs isoenzymes. Among the synthesized compounds, 2,2-dichloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide (f1) can also induce A549 cells apoptosis. Therefore, compound f1 might have a potential value for further study in drug development. QSAR studies of this class of compounds were also explored using a collection of chemometrics methods.