1366733-85-8

Basic information

• Product Name: Fmoc-Pro-Pro-O-pentafluorophenyl ester
• Synonyms: Fmoc-Pro-Pro-O-pentafluorophenyl ester
• CAS NO: 1366733-85-8
• Molecular Weight: 600.542
• Mol File: 1366733-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc-Pro-Pro-O-pentafluorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Pro-Pro-O-pentafluorophenyl ester(1366733-85-8)
• EPA Substance Registry System: Fmoc-Pro-Pro-O-pentafluorophenyl ester(1366733-85-8)

Safety Data

• Hazardous Substances Data: 1366733-85-8(Hazardous Substances Data)

Upstream product

• 129472-19-1 (9H-fluoren-9-yl)methyl tert-butylpyrrolidine-1,2-dicarboxylate 
• 129223-22-9 Fmoc-L-Pro-Pro-OH 
• 2812-46-6 proline tert-butyl ester 
• 71989-31-6 Fmoc-Pro-OH 
• 1366733-84-7 Fmoc-Pro-Pro-O-t-butyl ester 

Relevant articles and documents

Solution-phase synthesis and evaluation of tetraproline chiral stationary phases

A protocol was developed for the solution-phase synthesis of multigram amounts of two 9-fluorenylmethoxycarbonyl (Fmoc)-protected tetraproline peptides. These tetraproline peptides were then attached to amino derivatized silica gel. The replacement of the Fmoc group with the trimethylacetyl group lead to two tetraproline chiral stationary phases (CSPs). A comparison of the chromatographic behavior of these two solution-phase-synthesized tetraproline CSPs with that prepared by stepwise solid-phase synthesis revealed that all three had similar chromatographic performance for resolving 53 model analytes. This suggests that the solution-phase synthesis of oligoprolines, which allows for the specific benefits of good batch reproducibility, selector homogeneity, and possibly low cost, is a feasible alternative to the solid-phase synthesis of oligoproline CSPs. Copyright