13668-51-4Relevant academic research and scientific papers
Visible light mediated aerobic oxidative hydroxylation of 2-oxindole-3-carboxylate esters: An alternative approach to 3-hydroxy-2-oxindoles
Wang, Jinge,Osman, Siyitemer,Lu, Xinjiang,Chen, Junyi,Xia, Xu-Dong
, p. 168 - 175 (2020)
A convenient aerobic oxidative hydroxylation of 3-substituted oxindoles under mild reaction conditions is described herein. This process was accomplished by the activation of molecular oxygen in the air in the presence of a photocatalyst under the irradiation of visible light. The desired product was delivered in up to 89% yield without the addition of base or stoichiometric oxidant.
Phototandem catalysis: Efficient synthesis of 3-ester-3-hydroxy-2-oxindoles by a visible light-induced cyclization of diazoamides through an aerobic oxidation sequence
Xia, Xu-Dong,Ren, Yan-Liang,Chen, Jia-Rong,Yu, Xing-Long,Lu, Liang-Qiu,Zou, You-Quan,Wan, Jian,Xiao, Wen-Jing
, p. 124 - 128 (2015/02/05)
An unprecedented phototandem catalysis based on a single iridium photocatalyst has been successfully developed. This powerful strategy consists of two mechanistically distinct catalytic cycles, namely, photocatalytic energy transfer (ET) and single electron transfer (SET). The novel protocol allows a rapid and efficient construction of biologically and synthetically important 3-ester-3-hydroxy-2-oxindole derivatives from readily available diazoamides through a cyclization/aerobic oxidation sequence under very mild conditions.
Phenyliodine bis(trifluoroacetate)-mediated oxidative C-C bond formation: Synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides
Wang, Junwei,Yuan, Yucheng,Xiong, Rui,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
, p. 2210 - 2213 (2012/06/18)
The reaction of phenyliodine bis(trifluoroacetate) (PIFA) with a series of anilides 1 (E = CO2Et) in CF3CH2OH was found to give 3-hydroxy-2-oxindole derivatives 2, while that with various anilides 1′ (E = CON(R4
