136684-94-1

Basic information

• Product Name: N-cyclohexyl-4-fluoroaniline
• Synonyms: N-cyclohexyl-4-fluoroaniline;UKRORGSYN-BB BBV-132079;N-Cyclohexyl-4-Fluoroaniline(WXC04197)
• CAS NO: 136684-94-1
• Molecular Formula: C₁₂H₁₆FN
• Molecular Weight: 193.26
• Mol File: 136684-94-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclohexyl-4-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-4-fluoroaniline(136684-94-1)
• EPA Substance Registry System: N-cyclohexyl-4-fluoroaniline(136684-94-1)

Safety Data

• Hazardous Substances Data: 136684-94-1(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 98-89-5 Cyclohexanecarboxylic acid 
• 350-46-9 4-Fluoronitrobenzene 
• 108-95-2 phenol 
• 352-34-1 4-fluoro-1-iodobenzene 
• 108-91-8 cyclohexylamine 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 121883-35-0 cyclohexylzinc iodide 
• 3296-02-4 p-azidofluorobenzene 
• 931-50-0 cyclohexylmagnesium bromide 
• 404-38-6 4,4'-difluorodiphenyl sulfide 
• 475598-83-5 tris(4-fluorophenyl)sulfonium trifluoromethanesulfonate 
• 108-94-1 cyclohexanone 

Downstream Products

• 1056991-72-0 2-chloro-N-cyclohexyl-N-(4-fluorophenyl)acetamide 

Relevant articles and documents

Design, Synthesis, and Structure-Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists

5-HT1A receptor (5-HT1AR) agonists have been implicated in the treatment of a variety of central nervous system (CNS) diseases such as depression and anxiety, et al. Based on our previously found compound FW01 (Ki = 51 ± 16 nM) obtained by virtual screening, a series of FW01 derivatives were designed and synthesized by the modification of the amide tail group as well as indole headgroup of FW01. SAR exploration found that amide tail group and indole headgroup play pivotal roles in determining the binding affinity and selectivity on dopamine and serotonin receptor subtypes. Among all tested compounds, 9_24 has a Ki value of 5 ± 0.6 nM with a good selectivity toward 5-HT1AR. The [35S] GTPγS assay showed that 9_24 is a full agonist toward 5-HT1AR with an EC50 value of 0.059 nM, which shows 266.2 and 146.4-fold selectivity to 5-HT2A and D3 respectively. Molecular dynamics simulations and molecular docking studies with 5-HT1AR-9_24 were performed to disclose the mechanism of its high activity and selectivity. Finally, a detailed stepwise 9_24 induced signal transduction mechanism of 5-HT1AR is proposed.

Band-Gap Narrowing of Highly Stable Heterogeneous ZrO2–ZnO Nanocomposites for the Reductive Amination of Carbonyl Compounds with Formic Acid and Triethylamine

The band gap of a material can be affected by factors such as size, doping materials, and oxygen vacancies. The decrease in band gap and change in state of ZrO2 with the addition of ZnO indicates interfacial interactions between ZrO2 and ZnO in the nanocomposites (NCs), which is further confirmed by the observed shift of the peaks in the Raman spectra. Heterobimetallic ZrO2–ZnO NCs were synthesized through a sustainable green approach by using sucrose isolated from Angelica gigas Nakai root extract. The highly stable NCs displayed excellent catalytic activity for reductive amination of carbonyl compounds utilizing HCO2H/(CH3CH2)3N as a hydrogen source. The high catalytic performance of the NCs was closely correlated with the narrow band gap and synergistic effect of ZrO2 with ZnO in the NCs.