13670-60-5Relevant academic research and scientific papers
Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones
Liu, Jidan,Yang, Zhenke,Jiang, Jinyuan,Zeng, Qiaohai,Zheng, Liyao,Liu, Zhao-Qing
supporting information, p. 5927 - 5931 (2021/07/31)
The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.
Oxazoline-Promoted Rh-Catalyzed C-H Amidation of Benzene Derivatives with Sulfonamides and Trifluoroacetamide. A Comparative Study
Maiden, Tracy M.M.,Swanson, Stephen,Procopiou, Panayiotis A.,Harrity, Joseph P.A.
, p. 10641 - 10650 (2016/11/29)
A Rh-catalyzed ortho-amidation of 2-aryloxazolines offers an efficient and direct route to a range of sulfonamides. The scope of the reaction is very broad with respect to sulfonamide substrate, but the position and electronic nature of the substituents on the aryl moiety of the oxazoline lead to a surprising modulation of reactivity. The reactivity of sulfonamides in comparison to trifluoroacetamide is compared, the latter undergoing Rh-catalyzed amidation more rapidly.
Efficient oxidative synthesis of 2-oxazolines
Schwekendiek, Kirsten,Glorius, Frank
, p. 2996 - 3002 (2008/02/10)
New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity. Georg Thieme Verlag Stuttgart.
A simple synthesis of 2-substituted oxazolines and oxazines
Cwik, Agnieszka,Hell, Zoltán,Hegedüs, Adrienn,Finta, Zoltán,Horváth, Zoltán
, p. 3985 - 3987 (2007/10/03)
β-Aminoalcohols react with carboxylic acids in the presence of a zeolite, Ersorb-4, resulting in the formation of oxazoline derivatives in good yields. Similarly, 3-aminopropanol and benzoic acid gave the corresponding 2-phenyloxazine.
One-step conversion of aldehydes to oxazolines and 5,6-dihydro-4H-1,3-oxazines using 1,2- and 1,3-azido alcohols
Badiang, Jennifer G.,Aube, Jeffrey
, p. 2484 - 2487 (2007/10/03)
The reactions of 1,2- and 1,3-hydroxy azides with aldehydes under acidic conditions were examined. A variety of Lewis acids were examined, of which BF3·OEt2 was found the most convenient. Trimethylsilyl ether derivatives of the alcohols could also be reacted using trimethylsilyl triflate as the promoter. Twenty-five examples that proceed in moderate to quantitative yields are reported.
