136704-06-8

Upstream product

• 6457-49-4 4-piperidinemethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 136704-05-7 4-(2-cyano-2,2-diphenylethyl)-1-(4-methylphenylsulphonyl)piperidine 
• 136703-85-0 2-(2-Carbamoyl-2,2-diphenylethyl)-1-(4-chlorophenethyl)piperidine 

Relevant academic research and scientific papers

SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are alpha keto amide and alpha hydroxy amide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.

NEW ARYLPIPERAZINYL COMPOUNDS

The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by formula (I), and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.