136705-41-4Relevant academic research and scientific papers
Stereocontrolled Synthesis of 3-(Ethoxycarbonyl)-4-hydroxy-2-isoxazoline 2-Oxides. A New Approach to the Synthesis of 4-Hydroxylated 2-Isoxazolines
Rosini, Goffredo,Marotta, Emanuela,Righi, Paolo,Seerden, Jean Paul
, p. 6258 - 6260 (1991)
Treatment of 2-bromo aldehydes and ethyl nitroacetate with alumina without solvent, or in solution with a tertiary base, at room temperature gives the diastereomeric title compounds in fair yields by a tandem nitroaldol reaction-cyclization sequence opening a new route for the preparation of trans and cis 4-hydroxylated 2-isoxazolines in a predictable way.
