13672-26-9

Upstream product

• 1217-89-6 1-benzylisatin 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 125923-35-5 methyl (N¹-benzyl-3-indolyl)acetate 

Downstream Products

• 1448522-88-0 1-benzyl-3-(2-(7-chloroindolin-1-yl)-2-oxoethyl)indolin-2-one 
• 1448522-89-1 1-benzyl-3-(2-(7-bromoindolin-1-yl)-2-oxoethyl)indolin-2-one 
• 1448522-90-4 1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione 
• 1448522-91-5 (E)-1-(1-benzyl-2-oxoindolin-3-ylidene)-4,5-dihydropyrrolo[3,2,1-hi]indol-2(1H)-one 

Relevant academic research and scientific papers

Application of isatin-derived saturated esters in the synthesis of 3,3′-spirooxindole γ-butyrolactams

Stable while reactive isatin-derived saturated esters have been utilized as 3-carbon synthons in a base-promoted formal [3 + 2] annulation with N-Boc imines. The developed protocol offers a direct pathway for the rapid and divergent construction of two classes of 3,3′-spirooxindole γ-butyrolactam skeletons that are recognized as the privileged structures of various bioactive compounds. This protocol also has the advantages of mild reaction conditions, scalability and wide reaction scope.

Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B

Two palladium-catalysed amination protocols are deployed in the desymmetrisation of the complex dimeric alkaloid meso-chimonanthine. The power of these transformations is showcased in an efficient formal and total synthesis of the natural products hodgkinsine and hodgkinsine B, respectively. Two palladium-catalysed amination protocols are deployed in the desymmetrisation of the complex dimeric alkaloid meso-chimonanthine. The power of these transformations is showcased in efficient formal and total synthesis of the natural products hodgkinsine and hodgkinsine B (see figure), respectively. Copyright

Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives

We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3-indolyl)acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric ami