1367293-01-3Relevant academic research and scientific papers
The synthesis and biological activity of lipophilic derivatives of bicine conjugated with N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP)an inhibitor of glucosamine-6-phosphate synthase
Koszel, Dominik,Lacka, Izabela,Kozlowska-Tylingo, Katarzyna,Andruszkiewicz, Ryszard
experimental part, p. 167 - 173 (2012/07/13)
A series of bis-N,N-(2-hydroxyethyl)glycine (bicine) derivatives, conjugated with an inhibitor of glucosamine-6-phosphate synthase, have been synthesized and their lipophilic and antifungal properties have been tested. The obtained compounds demonstrated higher lipophilicity than free inhibitor (FMDP) and, in consequence, an increased potential to cross the cytoplasmic membrane. All the tested compounds show better antifungal activity than parent compound.
