1367359-32-7Relevant articles and documents
Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity
Hanrahan, Patrick,Bell, James,Bottomley, Gillian,Bradley, Stuart,Clarke, Phillip,Curtis, Eleanor,Davis, Susan,Dawson, Graham,Horswill, James,Keily, John,Moore, Gary,Rasamison, Chrystelle,Bloxham, Jason
, p. 2271 - 2278 (2012/05/04)
Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and Log D lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG.