136741-67-8

Basic information

• Product Name: 3-phenylbenzo[d]isoxazol-6-ol
• Synonyms: 3-phenylbenzo[d]isoxazol-6-ol
• CAS NO: 136741-67-8
• Molecular Formula: C₁₃H₉NO₂
• Molecular Weight: 211.21606
• Mol File: 136741-67-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-phenylbenzo[d]isoxazol-6-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylbenzo[d]isoxazol-6-ol(136741-67-8)
• EPA Substance Registry System: 3-phenylbenzo[d]isoxazol-6-ol(136741-67-8)

Safety Data

• Hazardous Substances Data: 136741-67-8(Hazardous Substances Data)

Upstream product

• 408531-49-7 2,4-dihydroxy-benzophenone-imine 
• 100-47-0 benzonitrile 
• 108-46-3 recorcinol 
• 131-56-6 2.4-dihydroxybenzophenone 
• 50593-96-9 2',4'-dihydroxybenzophenone oxime 
• 136741-51-0 6-Methoxy-3-phenyl-benzo[d]isoxazole 

Downstream Products

• 107804-69-3 7-acetoxymethyl-5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole 
• 107804-50-2 5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole-7-carboxylic acid 
• 107804-49-9 5-bromo-7,8-dihydro-3-phenylfuro<2,3-g>-1,2-benzisoxazole-7-methanol 
• 107804-46-6 3-Phenyl-7,8-dihydro-furo[3',2':3,4]benzo[1,2-d]isoxazole-7-carboxylic acid 
• 107804-45-5 7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-methanol 
• 107804-68-2 7-Allyl-3-phenyl-benzo[d]isoxazol-6-ol 
• 136741-77-0 6-Allyloxy-3-phenyl-benzo[d]isoxazole 

Relevant articles and documents

Triflic anhydride: A mild reagent for highly efficient synthesis of 1,2-benzisoxazoles, isoxazolo, and isothiazolo quinolines without additive or base

The synthetic utility of trifluoromethanesulphonic anhydride (triflic anhydride, TA) without additive or base for the high-yielding synthesis of a wide variety of 1,2-benzisoxazoles from 2-hydroxyaryl aldoximes and ketoximes under mild conditions has been carried out for the first time. As a continuation of our study, syntheses of isoxazolo and isothiazolo quinolones have also been demonstrated using triflic anhydride under similar conditions. This method is simple and has benefits from the easy way to isolate the products in excellent yields.

Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids

A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.