136743-24-3

Basic information

• Product Name: S-(4-methoxybenzyl)thioglycolylaminoethylsulfonylethyl-4-nitrophenyl carbonate
• Synonyms: S-(4-methoxybenzyl)thioglycolylaminoethylsulfonylethyl-4-nitrophenyl carbonate
• CAS NO: 136743-24-3
• Molecular Formula: C21H24 N2 O9 S2
• Molecular Weight: 0
• Mol File: 136743-24-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 750.4°Cat760mmHg
• Flash Point: 407.6°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 1.17E-23mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: S-(4-methoxybenzyl)thioglycolylaminoethylsulfonylethyl-4-nitrophenyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-methoxybenzyl)thioglycolylaminoethylsulfonylethyl-4-nitrophenyl carbonate(136743-24-3)
• EPA Substance Registry System: S-(4-methoxybenzyl)thioglycolylaminoethylsulfonylethyl-4-nitrophenyl carbonate(136743-24-3)

Safety Data

• Hazardous Substances Data: 136743-24-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H24N2O9S2/c1-30-16-6-2-14(3-7-16)19(25)34-20(26)18(24)22-10-12-33-13-11-31-21(27)32-17-8-4-15(5-9-17)23(28)29/h2-9,19-20,25-26H,10-13H2,1H3,(H,22,24)

Relevant articles and documents

Peptide purification method using novel linker and solid-phase ligand

Disclosed is a method of purifying a mature peptide with a free N-terminus group from a mixture of peptides comprising the mature peptide and immature end-capped peptides. The peptides are bound to a solid-phase support and are produced by solid phase synthesis. The mixture is contacted with a linker comprising a functional group at each terminus. The functional group at one terminus has the structure --SO2 --CH2 --CH2 --X, wherein X is an activated carbonate group which reacts selectively with N-terminus of the mature peptide to form a urethane linkage. The functional group at the other terminus is a thiol protected with an acid labile group. After cleaving the peptides from the solid support and thiol protecting group with acid, the mature peptide is separated from the mixture by forming a covalent bond between the liberated thiol and a solid support. Treatment with base cleaves the mature peptide from the linker to give a purified mature peptide.