1367456-46-9

Basic information

• Product Name: tert-butyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
• CAS NO: 1367456-46-9
• Molecular Weight: 368.476
• Mol File: 1367456-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate(1367456-46-9)
• EPA Substance Registry System: tert-butyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate(1367456-46-9)

Safety Data

• Hazardous Substances Data: 1367456-46-9(Hazardous Substances Data)

Upstream product

• 39515-51-0 3-Phenoxybenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1356700-11-2 4-((4-(3-phenoxybenzyl)piperazin-1-yl)sulfonyl)benzonitrile 
• 1356700-09-8 1-(4-isopropoxybenzyl)-4-(3-phenoxybenzyl)piperazine 
• 1356700-08-7 3-((4-(3-phenoxybenzyl)piperazin-1-yl)methyl)phenol 
• 1356700-07-6 1,4-bis(3-phenoxybenzyl)piperazine 
• 1356700-06-5 2-(4-chlorophenyl)-1-(4-(3-phenoxybenzyl)piperazin-1-yl)ethanone 
• 1356700-05-4 (4-methoxyphenyl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone 
• 1356700-04-3 4-(4-(3-phenoxybenzyl)piperazine-1-carbonyl)benzonitrile 
• 1356700-03-2 (4-chlorophenyl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone 
• 1356700-02-1 (4-isopropoxyphenyl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone 
• 1356700-01-0 (4-hydroxyphenyl)(4-(3-phenoxybenzyl)piperazin-1-yl)methanone 
• 1356700-00-9 (4-(3-phenoxybenzyl)piperazin-1-yl)(3-phenoxyphenyl)methanone 
• 1356699-99-4 (4-(3-phenoxybenzyl)piperazin-1-yl)(4-phenoxyphenyl)methanone 
• 114010-96-7 1-(3-phenoxybenzyl)piperazine 

Relevant articles and documents

Inhibition of noroviruses by piperazine derivatives

There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize an array of structurally-diverse derivatives which were screened for anti-norovius activity in a cell-based replicon system. The studies described herein demonstrate for the first time that functionalized piperazine derivatives possess anti-norovirus activity. Furthermore, these studies have led to the identification of two promising compounds (6a and 9l) that can be used as a launching pad for the optimization of potency, cytotoxicity, and drug-like characteristics.

PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.