1367486-35-8Relevant academic research and scientific papers
Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series
Lachance, Nicolas,Guiral, Sébastien,Huang, Zheng,Leclerc, Jean-Philippe,Li, Chun Sing,Oballa, Renata M.,Ramtohul, Yeeman K.,Wang, Hao,Wu, Jin,Zhang, Lei
scheme or table, p. 623 - 627 (2012/03/11)
Elevated levels of stearoyl-CoA desaturase (SCD) activity have been implicated in metabolic disorders such as obesity and type II diabetes. To circumvent skin and eye adverse events observed in rodents with systemically-distributed inhibitors, our research efforts have been focused on the search for new liver-targeting compounds. This work has led to the discovery of novel, potent and liver-selective acyclic linker SCD inhibitors. These compounds possess suitable cellular activity and pharmacokinetic properties to inhibit liver SCD activity in a mouse pharmacodynamic model.
