136758-99-1Relevant academic research and scientific papers
Phenylethanolaminomethyltetralins and pharmaceutical use
-
, (2008/06/13)
New phenylethanolaminomethyltetralins of formula (I) STR1 wherein E represents hydrogen, (C1 -C4)alkyl, (C1 -C4)alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents hydrogen, (C1 -C4)alkyl, (C1 -C4)alkyoxy, phenyl, nitro, or halogen, or E and L taken together represent a group --CH=CH--CH=CH-- or --CH2 --CH2 --CH2 --CH2 --, and G represents hydrogen, chloro, hydroxy or an --OG' group wherein G' represents a (C1 -C4 (alkyl group either unsubstituted or substituted with hydroxy, (C1 -C4)alkoxy, (C1 -C4)alkoxycarbonyl, carboxy, or (C3 -C7)cycloalkyl; a (C3 -C7)cycloalkyl group; or a (C2 -C4)alkanoyl group; and salts thereof, are described which showed to be active as intestinal motility modulating agents and intraocular hypertension lowering agents. Also described is a process for the preparation of the new compounds and the intermediates of formula (III) STR2 employed in said process.
