136775-95-6Relevant academic research and scientific papers
TWO LACTONE FORMATION REACTIONS FROM 1,3-DIOXIN-4-ONES HAVING HYDROXYALKYL GROUP AT THE 6-POSITION: DIFFERENCE IN RING OPENING AND CLOSURE
Sato, Masayuki,Sakaki, Jun-ichi,Sugita, Yoshiaki,Yasuda, Sanae,Sakoda, Hiroko,Kaneko, Chikara
, p. 5689 - 5708 (1991)
Two methods (A: ring opening to acylketenes followed by intramolecular ketene trapping and B: methoxide-mediated ring opening followed by cyclization of the hydroxy esters thus formed) have become available for the synthesis of lactones and/or cyclic ethers from 1,3-dioxin-4-ones having 1- 4-hydroxyalkyl group at the 6-position.Mechanism and scope of both methods have been clarified.
