136784-63-9Relevant academic research and scientific papers
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transpo
Deng, Yijun,Zhou, Xilin,Desmoulin, Sita Kugel,Wu, Jianmei,Cherian, Christina,Hou, Zhanjun,Matherly, Larry H.,Gangjee, Aleem
experimental part, p. 2940 - 2951 (2010/02/28)
A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines with bridge length variations (from 2 to 8 carbon atoms) were synthesized as selective folate receptor (FR) α and β substrates and as antitumor agents. The syntheses were accomplished
