1367878-82-7

Basic information

• Product Name: C₁₉H₂₁ClO₂
• Synonyms: C₁₉H₂₁ClO₂
• CAS NO: 1367878-82-7
• Molecular Weight: 316.828
• Mol File: 1367878-82-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₁ClO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₁ClO₂(1367878-82-7)
• EPA Substance Registry System: C₁₉H₂₁ClO₂(1367878-82-7)

Safety Data

• Hazardous Substances Data: 1367878-82-7(Hazardous Substances Data)

Upstream product

• 122024-75-3 3-<3-(phenylmethoxy)phenyl>-2-propenoic acid 
• 1383959-12-3 (4R)-3-[(3R)-1-oxo-3-[3-(phenylmethoxy)phenyl]pentyl]-4-phenyl-2-oxazolidinone 
• 1383959-11-2 (4R)-3-[(2E)-3-[3-(benzyloxy)phenyl]acryloyl]-4-phenyl-oxazolidin-2-one 
• 1367878-84-9 (αR,βR)-β-ethyl-α-methyl-3-(phenylmethoxy) benzenepropanoic acid 
• 1383959-14-5 (4R)-3-[(2R,3R)-2-methyl-1-oxo-3-[3-(phenylmethoxy)phenyl]pentyl]-4-phenyl-2-oxazolidinone 

Downstream Products

• 175591-09-0 tapentadol hydrochloride 
• 1383959-17-8 (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-(phenylmethoxy)benzenepropanamine 
• 1383959-16-7 (αR,βR)-β-ethyl-N,N,α-trimethyl-3-(phenylinethoxy)benzenepropanamide 
• 1384457-51-5 (αR,βR)-β-ethyl-3-hydroxy-N,N,α-trimethylbenzenepropanamide 

Relevant articles and documents

Substituted n-pentanamide compounds, preparation method and the use thereof

The present invention relates to a (2R, 3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.

SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

The present invention relates to a (2R, 3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.

A practical and enantioselective synthesis of tapentadol

A practical and enantioselective synthetic method for tapentadol has been described. Starting from inexpensive and readily available (E)-3-(3-(benzyloxy) phenyl)acrylic acid, tapentadol was prepared in seven steps (44% overall yield and 99.9% de) in more than 100 g batches, without any chromatographic purification. An Evans' chiral auxiliary based conjugate addition and alkylation were used as the key steps.