136795-65-8

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 943987-39-1 2-[2-(4-chlorophenyl)hydrazono]-2-(4-nitrophenyl)acetaldehyde 
• 943987-31-3 1-[4-(4-nitrophenyl)-1-phenyl-1H-3-pyrazolyl]-1-ethanone 
• 64989-98-6 4-(4-Nitrophenyl)-1-phenylpyrazol-3-carbonsaeure-ethylester 
• 943987-34-6 4-(4-nitrophenyl)-1-phenyl-3-phenylcarbamoyl-1H-pyrazole 
• 943987-36-8 [4-(4-nitrophenyl)-1-phenyl-1H-3-pyrazolyl](phenyl)methanone 
• 943987-30-2 1,3-diphenyl-4-(4-nitrophenyl)-1H-pyrazole 

Relevant academic research and scientific papers

Intramolecular interactions in nitroamines studied by 1H, 13C, 15N and 17O NMR spectral and quantum chemical methods

1H, 13C, 15N and 17O NMR chemical shifts are used for the characterization of the intramolecular interactions in several nitramines of the Me2N-G-NO2 type. The charge of lone electron pair

An efficient one-step method for the conversion of β-(dimethylamino) styrenes into arylacetonitriles

A new simple and efficient one-step method for the preparation of arylacetonitriles by reaction of β-(dimethylamino)styrenes with hydroxylamine hydrochloride in formic acid solution is described. Georg Thieme Verlag Stuttgart.

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors

In light of the emergence of resistance against the currently available EGFR inhibitors, our study focuses on tackling this problem through the development of dual EGFR/HER2 inhibitors with improved enzymatic affinities. Guided by the binding mode of the

Studies with enamines: Reactivity of N,N-dimethyl-N-[(E)-2-(4-nitrophenyl)- 1-ethenyl]amine towards nitrilimine and aromatic diazonium salts

(Chemical Equation Presented) In the presence of triethylamine, cycloaddition reaction of enamine 1 with hydrazonoyl halides 2 followed by dimethylamine elimination was achieved, yielding the corresponding 1,3,4-trisubstituted pyrazoles 4. Coupling of enamine 1 with aromatic diazonium salts afforded 2-(arylhydrazono)-2-(4-nitrophenyl)acetaldehyde 9 in good yield. Refluxing the phenyl hydrazone 9a with chloroacetone in ethanol in the presence of triethylamine afforded 1,3,5-trisubstituted pyrazole 12a, formed via intermediate 11a. Reaction of 9a with hydroxylamine hydrochloride in ethanol in the presence of anhydrous sodium acetate yielded oxime 13a which was irradiated in a microwave oven in the presence of acetic acid to afford a mixture of 15a and 16a.

A MILD METHOD FOR THE CONVERSION OF ACTIVATED ARYL METHYL GROUPS TO CARBOXALDEHYDES VIA THE UNCATALYZED PERIODATE CLEAVAGE OF ANAMINES

A mild procedure for the oxidative cleavage of aryl enamines to aryl aldehydes by periodate without the need for transition metal catalysis is presented.