136801-44-0

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 71316-14-8 N'-(4-methylphenyl)-N-(triphenylphosphoranylidene)-benzenecarboximidamide 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 15999-95-8 4-methylphenylbenzimidoyl chloride 

Relevant academic research and scientific papers

Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines

A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C–H activation/C–N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process.

A convenient synthesis of Quinazoline ring by tandem aza-Wittig reaction/electrocyclic ring closure

3,4-D-Dihydroquinazolines and Quinazolines were prepared starting from N'-aryl-N-(triphenylphosphoranilidene)-carboximidamides and aliphatic or aromatic aldehydes. The mechanism of the reaction is discussed.