136813-83-7

Upstream product

• 136813-82-6 (2S,4aS,5R,8aR)-2-Bromomethyl-7-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxymethoxy-4,4a,5,8-tetrahydro-benzo[1,3]dioxine-8a-carboxylic acid ethyl ester 
• 136786-28-2 (2R,4aS,7R,8aS)-2-Bromomethyl-4,4a,7,8-tetrahydro-benzo[1,3]dioxine-7,8a-dicarboxylic acid 7-tert-butyl ester 8a-ethyl ester 
• 136786-29-3 (1aS,2R,3aS,5R,7aR,7bR)-5-Bromomethyl-hexahydro-1,4,6-trioxa-cyclopropa[a]naphthalene-2,3a-dicarboxylic acid 2-tert-butyl ester 3a-ethyl ester 
• 136786-30-6 (2R,4aR,5S,8aS)-2-Bromomethyl-5-hydroxy-4,4a,5,8-tetrahydro-benzo[1,3]dioxine-7,8a-dicarboxylic acid 7-tert-butyl ester 8a-ethyl ester 
• 136786-27-1 (2E,4E)-6-[2-Bromo-1-(1-ethoxycarbonyl-vinyloxy)-ethoxy]-hexa-2,4-dienoic acid tert-butyl ester 
• 136786-31-7 (2S,4aS,5R,8aR)-2-Bromomethyl-5-hydroxy-7-hydroxymethyl-4,4a,5,8-tetrahydro-benzo[1,3]dioxine-8a-carboxylic acid ethyl ester 
• 136786-23-7 (2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienoic acid tert-butyl ester 
• 136786-26-0 2-(1,2-Dibromo-ethoxy)-acrylic acid ethyl ester 
• 136786-24-8 tert-butyl (E,E)-6-hydroxyhexa-2,4-dienoate 
• 136786-25-9 2-Vinyloxy-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Studies directed toward the total synthesis of tetronolide 2. A stereoselective route to the racemic cyclohexene subunit

A short stereo selective sequence is described for the preparation of the racemic form of the highly functionalized cyclohexene derivative 2 which comprises the upper segment of tetronolide (1), the aglycone of the antitumor tetrocarcins. A key element of this route is rapid assembly and intramolecular cycloaddition of the trienyl enol pyruvate 4, which achieves complete control over regiochemistry and good stereochemical control.