136831-49-7 Usage
Uses
Tyrphostin RG 14620 is a non-phenolic tyrphostin analog selective for the EGF receptor.
Biological Activity
rg-14620 is a tyrosine kinase and epidermal growth factor (egf) receptor [1].protein tyrosine kinases (ptks) have been involved in regulating cell proliferation, cell differentiation, and signaling processes in the immune system. dysfunction of protein tyrosine kinases result in inflammatory responses and diseases including cancer, atherosclerosis, and psoriasis [2]. the epidermal growth factor receptor (egfr) is a transmembrane glycoprotein. activation of egfr results in autophosphorylation of receptor tyrosine kinase and has been involved in regulating cellular proliferation, differentiation, and survival. overexpression of egfr has been identified in a variety of tumor cell lines and has been associated with poor prognosis and decreased survival [3].rg-14620 inhibited the activity of epidermal growth factor (egf) receptor kinase with an ic50 value of 3 μm in ht-22 cells [1]. rg-14620 suppressed not only egf-stimulated cancer cell proliferation in vitro but also tumor growth in nude mice [4]. tyrphostin rg-14620 dose-dependently inhibited the egfr-associated tyrosine kinase with half maximal inhibition at 7 μm [5].
references
[1] sagara, y. , ishige, k., tsai, c., et al. tyrphostins protect neuronal cells from oxidative stress. the journal of biological chemisty, 277(39), 36204-36215(2002).[2] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.[3] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.[4] yoneda t, lyall r m, alsina m m, et al. the antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice[j]. cancer research, 1991, 51(16): 4430-4435.[5] piontek m, hengels k j, porschen r, et al. antiproliferative effect of tyrosine kinase inhibitors in epidermal growth factor-stimulated growth of human gastric cancer cells[j]. anticancer research, 1992, 13(6a): 2119-2123.
Check Digit Verification of cas no
The CAS Registry Mumber 136831-49-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,8,3 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 136831-49:
(8*1)+(7*3)+(6*6)+(5*8)+(4*3)+(3*1)+(2*4)+(1*9)=137
137 % 10 = 7
So 136831-49-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4+
