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136845-59-5

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136845-59-5 Usage

Description

(3R,4aS,6R,8aS)-6-(2H-tetrazol-5-ylmethyl)decahydroisoquinoline-3-carboxylic acid is a complex organic compound featuring a tetrazole group attached to a decahydroisoquinoline-3-carboxylic acid core. It is a stereochemically defined compound with specific 3R, 4aS, 6R, and 8aS configurations. The presence of the tetrazole group makes it potentially useful as a drug candidate, as tetrazole-containing compounds have shown diverse biological activities. However, the specific properties and applications of this compound would need to be further researched and determined.

Uses

Used in Pharmaceutical Industry:
(3R,4aS,6R,8aS)-6-(2H-tetrazol-5-ylmethyl)decahydroisoquinoline-3-carboxylic acid is used as a potential drug candidate for [application reason] due to its tetrazole group, which is known to confer diverse biological activities. Further research is required to determine its specific applications and therapeutic potential.
(Note: The specific application reason is not provided in the materials, so it has been left blank. Further research would be needed to fill in this information.)

Check Digit Verification of cas no

The CAS Registry Mumber 136845-59-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,8,4 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 136845-59:
(8*1)+(7*3)+(6*6)+(5*8)+(4*4)+(3*5)+(2*5)+(1*9)=155
155 % 10 = 5
So 136845-59-5 is a valid CAS Registry Number.

136845-59-5Downstream Products

136845-59-5Relevant articles and documents

Stereoselective Synthesis of 6-Substituted Decahydroisoquinoline-3-carboxylates: Intermediates for the Preparation of Conformationally Constrained Acidic Amino Acids

Ornstein, Paul L.,Augenstein, Nancy K.,Arnold, M. Brian

, p. 7862 - 7869 (2007/10/02)

In this article we describe the stereoselective preparation of two 6-(hydroxymethyl) substituted decahydroisoquinoline-3-carboxylates, which are useful in the synthesis of a number of excitatory amino acid antagonists, e.g., (-)-1a (LY235959), (-)-2a (LY202157) and (-)-3a (LY293558).For example, the known ketone 4 was converted to either the (3SR,4aRS,6SR,8aRS)-alcohol 18 or the (3SR,4aRS,6RS,8aRS)-alcohol 21, the former via a stereoselective hydroboration reaction, the latter via a stereoselective enol ether hydrolysis followed by reduction.These C-6 epimeric alcohols were easily converted to a number of useful intermediates, e.g., aldehydes, bromides and iodides.If we used resolved keone 4, then these intermediates could be obtained in optically active form.In either racemic or non-racemic form, these intermediates provided access to a number of diastereomerically pure amino acids that were difficult to obtain by earlier routes.

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