13685-26-2

Usage

Uses

1. Used in Catalyst Property Tuning:
Chlorobis(4-chlorophenyl)phosphine, 98+% is used as a catalyst modifier for tuning the properties of catalysts. Its unique structure allows it to interact with other molecules and alter the catalyst's performance, making it a valuable component in the development of efficient and selective catalysts.
2. Used as Primary and Secondary Intermediates:
Chlorobis(4-chlorophenyl)phosphine, 98+% is also utilized as a primary and secondary intermediate in the synthesis of various organic and inorganic compounds. Its reactivity and structural features make it a versatile building block for creating complex molecules with specific properties and functions.
Different applications in different industries:
A. Used in Pharmaceutical Industry:
Chlorobis(4-chlorophenyl)phosphine, 98+% is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure and reactivity enable the creation of novel drug candidates with potential therapeutic applications.
B. Used in Chemical Industry:
In the chemical industry, Chlorobis(4-chlorophenyl)phosphine, 98+% is employed as a key intermediate in the production of various specialty chemicals, including agrochemicals, dyes, and polymer additives. Its high purity and reactivity make it an essential component in the synthesis of these high-value products.
C. Used in Material Science:
Chlorobis(4-chlorophenyl)phosphine, 98+% is also used in the field of material science for the development of new materials with specific properties. Its unique structure and reactivity can be exploited to create materials with enhanced performance characteristics, such as improved thermal stability, mechanical strength, or electrical conductivity.

InChI:InChI=1/C12H8Cl3P/c13-9-1-5-11(6-2-9)16(15)12-7-3-10(14)4-8-12/h1-8H

Upstream product

• 15948-60-4 bis(4-chlorophenyl)phosphine oxide 
• 106-39-8 bromochlorobenzene 

Relevant academic research and scientific papers

Twofold C?H Activation-Based Enantio- and Diastereoselective C?H Arylation Using Diarylacetylenes as Rare Arylating Reagents

C?H bond activation has been established as an attractive strategy to access axially chiral biaryls, and the most straightforward method is direct C?H arylation of arenes. However, the arylating source has been limited to several classes of reactive and bulky reagents. Reported herein is rhodium-catalyzed 1:2 coupling of diarylphosphinic amides and diarylacetylenes for enantio- and diastereoselective construction of biaryls with both central and axial chirality. This twofold C?H activation reaction stays contrast to the previously explored Miura–Satoh type 1:2 coupling of arenes and alkynes in terms of chemoselectivity and proceeded under mild conditions with the alkyne acting as a rare arylating reagent. Both C?H activation events are stereo-determining and are under catalyst control, with the 2nd C?H activation being diastereo-determining in a remote fashion. Analysis of the stereochemistry of the major and side products suggests moderate enantioselectivity of the initial C?H activation–desymmetrization process. However, the minor (R) rhodium vinyl intermediate is consumed more readily in undesired protonolysis, eventually resulting in high enantio- and diastereoselectivity of the major product.

Palladium-Catalyzed Cascade C?O Cleavage and C?H Alkenylation of Phosphinyl Allenes: An Expeditious Approach to 3-Alkenyl Benzo[b]phosphole Oxides

A phosphine oxide-directed intramolecular cyclization of phosphinyl allenes is established for the first time. The palladium-catalyzed intramolecular cyclization provides an unprecedented cascade C?O cleavage and direct C?H alkenylation toward novel 3-alk

Haloalkylation process

A process for the haloalkylation of certain tin, phosphorus and germanium halides is disclosed. The process is carried out typically in a halocarbon solvent at temperatures of less than 0° C. using as the haloalkylating reagent an admixture of a haloalkyl halide and tris(lower alkylamino)phosphine.