1368806-71-6

Basic information

• Product Name: 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-mercaptoisobutyryl)aminopentyl]amide
• Synonyms: 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-mercaptoisobutyryl)aminopentyl]amide
• CAS NO: 1368806-71-6
• Molecular Weight: 389.519
• Mol File: 1368806-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-mercaptoisobutyryl)aminopentyl]amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-mercaptoisobutyryl)aminopentyl]amide(1368806-71-6)
• EPA Substance Registry System: 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-mercaptoisobutyryl)aminopentyl]amide(1368806-71-6)

Safety Data

• Hazardous Substances Data: 1368806-71-6(Hazardous Substances Data)

Upstream product

• 932-90-1 syn-benzaldehyde oxime 
• 1368806-65-8 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylisobutyryl)aminopentyl]amide 
• 1368806-58-9 tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate 
• 1368806-59-0 C₁₆H₂₁N₃O₂ 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 1143-82-4 ethyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 698-16-8 benzohydroximoyl chloride 

Relevant articles and documents

Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

Mercaptoacetamide-based ligands have been designed as a new class of histone deacetylase (HDAC) inhibitors for possible use in the treatment of neurodegenerative diseases. The thiol group of these compounds provides a key binding element for interaction with the catalytic zinc ion, and thus differs from the more typically employed hydroxamic acid based zinc binding groups. Herein we disclose the chemistry and biology of some substituted mercaptoacetamides with the intention of increasing HDAC6 isoform selectivity while maintaining potency similar to their hydroxamic acid analogues. The introduction of a stereocenter α to the thiol group was found to have a considerable impact on HDAC inhibitor potency. These new compounds were also profiled for their therapeutic potential in an invitro model of stress-induced neuronal injury and were found to act as nontoxic neuroprotective agents.