136918-79-1Relevant academic research and scientific papers
Process for making 5-amino-1,2,3-thiadiazoles
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, (2008/06/13)
5-amino-1,2,3-thiadiazoles of the formula STR1 are made by reacting halogenoacetaldehydes of the formula with hydrazine derivatives of the formula preferably in an aqueous medium or in a mixture of an aqueous medium with organic solvents so as to form acylhydrazones of the formula whereupon the latter are reacted with thionylchloride of the formula whereby 5-halogeno-1,2,3-thiadiazoles are formed which are then reacted with ammonia preferably in the presence of a catalyst such as a mineral acid or Lewis acid whereby the desired product is obtained. The products are useful in making plant protection agents and herbicides such as the 1,2,3-thiadiazolyl-urea derivatives.
