1369181-92-9Relevant academic research and scientific papers
Method for electrochemically synthesizing 1, 2 and 4 - triazole compounds
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Paragraph 0022-0037; 0050-0053, (2020/10/20)
The invention discloses a method of electrochemically synthesizing a 1, 2, 4-triazole compound. The method includes: dissolving a compound (I) and quaternary ammonium salt into acetonitrile, stirringat room temperature of 50 DEG C to obtain reaction liqui
PhI(OAc) 2 -Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5- a ]pyridines via Oxidative N-S and N-N Bond Formation
Krishna, Palakodety Radha,Mangarao, Nakka,Nagaraju, Tumula,Sridhar, Balasubramanian
, p. 3600 - 3610 (2019/09/30)
An effective and expeditious approach for the construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5- a ]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc) su
Intramolecular electrochemical dehydrogenative N-N bond formation for the synthesis of 1,2,4-triazolo[1,5-a] pyridines
Li, Yong,Ye, Zenghui,Chen, Na,Chen, Zhenkun,Zhang, Fengzhi
supporting information, p. 4035 - 4039 (2019/08/07)
A metal- and oxidant-free intramolecular dehydrogenative N-N bond formation has been developed under mild and scalable electrolytic conditions. Various valuable 1,2,4-triazolo[1,5-a]pyridines were synthesized efficiently from the readily available N-(2-pyridyl)amidines. The reactions were conducted in a simple undivided cell under constant current conditions with nBu4NBr as both the redox mediator and the electrolyte. This protocol was applied to the efficient synthesis of key intermediates for anti-diabetic compounds.
A 1, 2, 4-triazole derivative synthesis method
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Paragraph 0118-0120, (2016/12/01)
The invention provides a 1,2,4-triazole derivative and a preparation method thereof. The method comprises the following steps: after mixing amidine or o-aminopyridine with a nitrile compound, copper acetate monohydrate, phenanthroline and sodium carbonate, adding an organic solvent; reacting for 12-24 hours in air at 110-120 DEG C; extracting the obtained product by ethyl acetate; drying by anhydrous sodium sulfate; decompressing and concentrating to obtain a coarse product; carrying out column chromatography isolation to obtain the 1,2,4-triazole derivative. Compared with the prior art, the method provided by the invention has the advantages that (1) the method is carried out in an air atmosphere, so that the cost is low; (2) no noble metals, strong bases and organic oxidizing agents are used but copper acetate monohydrate is used as a catalyst, so that the cost is saved; (3) by using amine and nitrile as reaction raw materials, the raw materials are easy to obtain; (4) the synthetic method is high in efficiency, wide in using range and suitable for various substrate reactions.
An efficient and recyclable heterogeneous catalytic system for the synthesis of 1,2,4-triazoles using air as the oxidant
Meng, Xu,Yu, Chaoying,Zhao, Peiqing
, p. 8612 - 8616 (2014/03/21)
Copper-zinc supported on Al2O3-TiO2 was found as a simple and efficient heterogeneous catalyst for the oxidative synthesis of 1,2,4-triazole derivatives using air as the green oxidant under ligand-, base- and additive-free conditions. The heterogeneous reactions carried out smoothly with a large range of substrates, including NO2-, vinyl-, pyrimidine- and imidazole-contained starting materials, and provided corresponding triazoles in moderate to excellent yields with low catalyst loading (1.6 mol%). Furthermore, the catalyst can be simply recycled many times without significant loss in catalytic activity. The Royal Society of Chemistry.
