136927-63-4

Basic information

• Product Name: Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)
• Synonyms: Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI);Pyrrolo[1,2-a]pyrazin-1(2H)-one;Pyrrolo[1,2-a]pyrazin-1-one;2H-pyrrolo[1,2-a]pyrazin-1-one
• CAS NO: 136927-63-4
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.13534
• Product Categories: AMINETERTIARY
• Mol File: 136927-63-4.mol

Chemical Properties

• Boiling Point: 213℃
• Flash Point: 83℃
• Appearance: /
• Density: 1.33
• Vapor Pressure: 0.166mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.34±0.20(Predicted)
• CAS DataBase Reference: Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)(136927-63-4)
• EPA Substance Registry System: Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)(136927-63-4)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 136927-63-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds due to its unique heterocyclic structure and potential biological activity.
Used in Drug Development:
Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI) is utilized as a lead compound in drug discovery and development processes, where its structural features and potential interactions with biological targets are explored for the creation of new therapeutic agents.
Note: Since the provided materials do not specify particular applications or industries for Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI), the uses listed are general and based on the compound's potential in pharmaceutical research and drug development. Further information or research would be needed to identify specific applications in different industries.

InChI:InChI=1/C7H6N2O/c10-7-6-2-1-4-9(6)5-3-8-7/h1-5H,(H,8,10)

Upstream product

• 219783-00-3 (+/-)-longamide 
• 136927-43-0 2,2,2-trichloro-1-(1-(2,2-diethoxyethyl)-1H-pyrrol-2-yl)ethan-1-one 
• 136927-42-9 1-(2,2-diethoxyethyl)-1H-pyrrole 
• 4513-94-4 1H-pyrrole-2-carbonitrile 

Downstream Products

• 136927-64-5 1-chloropyrrolo[1,2-a]pyrazine 
• 918340-62-2 2-chloro-5-(pyrrolo[1,2-a]pyrazin-1-ylamino)-phenol 

Relevant articles and documents

Synthesis of Hydroxypyrrolone Carboxamides Employing Selectfluor

Reaction of pyrrole-2-carboxamides with Selectfluor in MeCN/water (4:1) affords 2-hydroxy-5-oxopyrrole-2-carboxamides in yields of up to 80 %. A variety of sensitive functional groups is tolerated, among them aldehydes and alkynes. The new method also wor

SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co

COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRUSES AND CANCER

The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group;; R2 , R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H); R is H or an optionally substituted C1-C6 alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.