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Upstream product

• 497968-93-1 7,13-bis(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecane-8,12-dione 
• 497968-92-0 1,10-bis(2-methoxyphenyl)-4,7-dioxa-1,10-diazadecane 
• 90-04-0 2-methoxy-phenylamine 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 68-12-2 N,N-dimethyl-formamide 
• 182926-58-5 7,13-bis(2-methoxyphenyl)-1,4,10-trioxa-7,13-diazacyclopentadecane 

Relevant academic research and scientific papers

CYTOSOLIC FLUORESCENT ION INDICATORS

Novel fluorophores for fluorescent ion indicators incorporate water-solubilizing functional groups. These fluorophores enable visible-wavelength analysis of ion concentrations with chelators that are insoluble or poorly soluble in water. A green version of the fluorophore comprises a putative fluorescein with carboxylate appendages. An orange version of the fluorophore comprises a putative rhodamine, also with carboxylate appendages. Attaching the fluorophore to a 12-crown-4, a 15-crown-5, a 18-crown-6, a 21-crown-7, or a 24-crown-8 produces lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to diaza [1,1,1], [1,1,2], [1,2,2], [2,2,2], [2,2,3], [2,3,3], or [3,3,3] cryptands produces more selective lithium, sodium, potassium, rubidium, and cesium indicator families, respectively. Attaching the fluorophore to BAPTA, APTRA, or half- BAPTA or their analogs produces new calcium, magnesium, and other metal ions indicator families that strongly resist leakage from the cell.