136933-41-0Relevant academic research and scientific papers
Synthesis of novel cephem-4-ketones. A new series of human leukocyte elastase inhibitors
Alpegiani, Marco,Bissolino, Pierluigi,Perrone, Ettore,Cassinelli, Giuseppe,Franceschi, Giovanni
, p. 6207 - 6210 (2007/10/02)
Alkylation of cephem-4-carbonyl chlorides at the sulphide or sulphone oxidation level with Grignard reagents, stannanes and cuprates is described. Radical or ionic bromination of the 3-methylcephem-4-ketone 8, followed by displacement with heterocyclic th
