136933-63-6

Upstream product

• 186503-36-6 (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 186503-35-5 (6R,7S)-7-Methoxy-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 126621-86-1 7α-Methoxy-3-methyl-3-cephem-4-carboxylic acid 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 
• 126598-07-0 7α-methoxy-3-methyl-Δ³-cephem-4-carbonyl chloride 
• 186503-37-7 (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5,5,8-trioxo-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 204376-70-5 (6R,7S)-2-Benzoyl-7-methoxy-3-methyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-8-one 

Downstream Products

• 159518-00-0 2α-bromo-3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide 
• 159651-44-2 2α-bromo-7α-methoxy-3-methyl-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide 
• 159425-17-9 3-(bromomethyl)-7α-methoxy-4-(phenylcarbonyl)-Δ³-cephem 1,1-dioxide 

Relevant academic research and scientific papers

Novel preparation of 1,1-dioxo-7α-methoxy-3-methyl-Δ3 -cephem-4-yl aryl ketones

1,1-Dioxo-7α-methoxy-3-methyl-Δ3-cephem-4-yl phenyl ketone, a valuable precursor of potent HLE inhibitors, was obtained in an efficient way starting from 7α-methoxy-3-methyl-Δ3-cephem-4-carboxylic acid. By employing the same methodology a variety of 1,1-dioxocephem-4-yl aryl ketones were prepared.

Cephem sulfones as inactivators of human leukocyte elastase. 5. 7α- Methoxy- and 7α-chloro-1,1-dioxocephem 4-ketones

Studies on cephem sulfones as inhibitors of human leukocyte elastase (HLE) have been extended to the new class of cephem 4-ketones. tert-Butyl and phenyl ketones were prepared from 4-carboxycephem derivatives, at either the sulfide or sulfone oxidation le