1369423-48-2Relevant academic research and scientific papers
Benzylic phosphates as electrophiles in the palladium-catalyzed asymmetric benzylation of azlactones
Trost, Barry M.,Czabaniuk, Lara C.
supporting information; experimental part, p. 5778 - 5781 (2012/05/07)
Palladium-catalyzed asymmetric benzylation has been demonstrated with azlactones as prochiral nucleophiles in the presence of chiral bisphosphine ligands. Benzylic electrophiles are utilized under two sets of reaction conditions to construct a new tetrasubstituted stereocenter. Electron density of the phenyl ring dictates the reaction conditions, including the leaving group. The reported methodology represents a novel asymmetric carbon-carbon bond formation in an amino acid precursor.
