1369424-65-6Relevant academic research and scientific papers
Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules
Mndez, Luciana,Mata, Ernesto G.
, p. 81 - 86 (2015)
Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.
arone and amide compound and its preparation and use in medicine
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, (2017/11/17)
The invention discloses a novel arone and arylamide compound represented by formula I, a cistrans isomer, physiologically acceptable salts, a solvate and a crystallizing form thereof, a preparation method of the compound, a medicine preparation containing the compound and clinical application of the compound in treating diseases related to protein tyrosine phosphatases 1B.
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors
Tang, Yan-Bo,Lu, Dianyun,Chen, Zheng,Hu, Chun,Yang, Ying,Tian, Jin-Ying,Ye, Fei,Wu, Li,Zhang, Zhong-Yin,Xiao, Zhiyan
, p. 2313 - 2318 (2013/05/09)
Fifteen novel sulfathiazole-related compounds were designed as PTP1B inhibitors based on a previously reported allosteric inhibitor (1) of PTP1B. These compounds were synthesized and evaluated against human recombinant PTP1B. Six compounds (3, 4, 8 and 14
