136944-07-5

Upstream product

• 1314025-23-4 1'-(3,4-methylenedioxyphenyl)-2'-(4''-methoxyphenyl)ethan-2'-one 
• 274-09-9 Methylenedioxybenzene 
• 136944-05-3 2-Benzo[1,3]dioxol-5-yl-1-(4-methoxy-phenyl)-2-methylsulfanyl-ethanone 
• 91761-42-1 dimethyl (1,3-benzodioxol-5-yl)-hydroxymethylphosphonic acid 
• 120-57-0 piperonal 
• 136944-00-8 2-Chloro-1-(4-methoxy-phenyl)-2-methylsulfanyl-ethanone 
• 46188-84-5 1‐(4‐methoxyphenyl)‐2‐(methylsulfanyl)ethanone 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization

Structure-activity relationships for rigid analogues of combretastatin A-4 (CA-4) were investigated, leading to the discovery of a series of 3,4-diaryl-1,2,5-oxadiazole-N-oxides. Among them, 7n′ and 7n′′ showed remarkable antiproliferative activities agai

BF3·OEt2-mediated [1,2]-aryl shift: Synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin

A new sequential, tandem synthesis of functionalized α-arylnitriles via the bromination/cyanation/deformylation of substituted deoxybenzoin has developed. CuBr2-promoted bromination of substituted deoxybenzoins gives 2-bromo-2-arylacetophenne 3. The cyanation of 3 with sodium cyanide (NaCN) generates epoxynitrile. Then, a treatment of epoxynitrile with BF3·OEt2 results in the formation of functionalized α-arylnitriles 4 via a 1,2-aryl shift.

Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4

A set of novel selenium-containing heterocyclic analogues of combretastatin A-4 (CA-4) have been designed and synthesised using a rigid 1,2,5-selenadiazole as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evalu

Synthesis of unsymmetrically substituted benzils via the Friedel-Crafts reaction of arenes with α-chloro-α-(methylthio)acetophenones

Lewis acid-promoted reactions of arenes with α-chloro-α-(methylthio)acetophenones gave the Friedel-Crafts reaction products, which were then treated with 3 molar eq of cupric chloride in aqueous acetone to afford the unsymmetrically substituted benzils.