136944-20-2Relevant academic research and scientific papers
Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis
Jo, Hyeju,Choi, Minho,Sim, Jaeuk,Viji, Mayavan,Li, Siyuan,Lee, Young Hee,Kim, Youngsoo,Seo, Seung-Yong,Zhou, Yuanyuan,Lee, Kiho,Kim, Wun-Jae,Hong, Jin Tae,Lee, Heesoon,Jung, Jae-Kyung
, p. 3374 - 3377 (2017)
We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed t
Skin Whitening Composition Comprising Caffeic Acid Derivatives as the Active Ingredients
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Paragraph 0093; 0135-0139, (2020/02/11)
The present invention relates to a skin whitening composition containing a new caffeic acid derivative compound as an active ingredient. According to the present invention, the caffeic acid derivative compound can be developed for a skin whitening cosmetic product or for a medicine for the hyperpigmentation of melanin because having skin whitening activity by inhibiting the biosynthesis of melanin in melanocytes.
Novel Chlorogenic Acid Derivatives and Composition for Treating Inflammatory Disease Comprising the Same
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Paragraph 0235; 0236; 0237; 0238, (2017/08/02)
The present invention relates to a novel chlorogenic acid derivative compound having anti-inflammatory activities and an anti-inflammatory composition comprising the same as an active ingredient. The chlorogenic acid derivative compound of the present invention inhibits overproduction of nitrogen oxide (NO) induced by treating LPS in macrophage. The chlorogenic acid derivative compound of the present invention suppresses activation of NF-κB which is a signal transmission-mediated transcription factor significant in an oxidative stress and inflammation-promoting path. The chlorogenic acid derivative compound of the present invention can be developed as medicine for various inflammatory diseases by inhibiting overproduction of nitrogen oxide and activation of NF-κB.
Novel Chlorogenic Acid Derivatives and Composition for Treating Inflammatory Disease Comprising the Same
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Paragraph 0206-0210, (2021/05/22)
The present invention relates to a novel chlorogenic acid derivative compound having anti-inflammatory activities and to an anti-inflammatory composition including the same as an active ingredient. The chlorogenic acid derivative compound of the present invention controls the overproduction of nitrogen oxide (NO) derived by the treatment of LPS in histiocytes. The chlorogenic acid derivative compound of the present invention inhibits the activation of NF-κB which is an important signal transmittal intermediated transcription factor in oxidant stress and inflammation promoting routes. The chlorogenic acid derivative compound of the present invention has a high possibility of being developed into an agent for treating various inflammatory diseases by inhibiting the overproduction of NO and the activation of NF-κB.
